NSC 5844
NSC5844
CAS: 140926-75-6
Molecular Formula: C20H16Cl2N4
NSC 5844 - Names and Identifiers
| Name | NSC5844 |
| Synonyms | RE640 RE 640 RE640 RE-640 NSC5844 RE-640 RE 640 NSC 5844 NSC-5844 NSC5844 (RE640) N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine 1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)- |
| CAS | 140926-75-6 |
NSC 5844 - Physico-chemical Properties
| Molecular Formula | C20H16Cl2N4 |
| Molar Mass | 383.27 |
| Density | 1.431±0.06 g/cm3(Predicted) |
| Boling Point | 632.6±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 6.61±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI 50 s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum , inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum , with IC 50 s of 17 and 27 nM, respectively. |
NSC 5844 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.609 ml | 13.046 ml | 26.091 ml |
| 5 mM | 0.522 ml | 2.609 ml | 5.218 ml |
| 10 mM | 0.261 ml | 1.305 ml | 2.609 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
NSC 5844 - Reference Information
| Biological activity | NSC5844 is a 4-aminoquinoline derivative with anti-tumor and anti-malaria activity. |
| target | Parasite |
| in vitro study | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI 50 s of 7.35±0.10 μM and 14.80±0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum , inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of p. falciparum , with IC 50 s of 17 and 27 nM, respectively. |
Last Update：2024-04-09 02:00:01
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Product Name: RE-640 Visit Supplier Webpage Request for quotationCAS: 140926-75-6
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Product Name: N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine Visit Supplier Webpage Request for quotationCAS: 140926-75-6
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View History
NSC 5844
2-(3,4-二甲氧基苯基)噻唑-4-羧酸乙酯
BOC-L-Leu-Gly-L-Arg-PNA.HCL
IBT6A HYDROCHLORIDE
SINEFUNGIN
4-硝基苯硫代异氰酸酯
Boronic acid, B-[2-[(1,1-dimethylethoxy)methyl]phenyl]-
6-磷酸葡萄糖酸三钠盐
2-甲基噁唑-5-羧酸
Ceriumisopropoxide
2-(3,4-二甲氧基苯基)噻唑-4-羧酸乙酯
BOC-L-Leu-Gly-L-Arg-PNA.HCL
IBT6A HYDROCHLORIDE
SINEFUNGIN
4-硝基苯硫代异氰酸酯
Boronic acid, B-[2-[(1,1-dimethylethoxy)methyl]phenyl]-
6-磷酸葡萄糖酸三钠盐
2-甲基噁唑-5-羧酸
Ceriumisopropoxide